糖尿病性骨质疏松症(DOP)是糖尿病患者常见的并发症,其主要特征为骨密度降低、骨微结构破坏和骨折风险增加。这种病症不仅增加了患者的生活负担,还显著影响了生活质量,并给医疗系统带来了沉重压力。随着全球糖尿病患病率的持续上升,DOP的防治需求愈加迫切。中医药在调理慢性病和增强体质方面具有独特优势,尤其适合复杂慢性病的管理。中医药通过调节糖代谢、骨代谢以及抗炎、抗氧化和免疫调节等多重作用,在防治DOP方面展现出良好的疗效。研究旨在系统探讨中医药在DOP防治中的作用及具体机制。通过总结和分析现有的临床与实验研究,验证传统中药方剂、单味中药及中医外治法在DOP防治中的有效性。深入研究中医药调节糖代谢、骨代谢的具体途径,揭示其在整体干预DOP病程中的作用机制。Diabetic osteoporosis (DOP) is a common complication in patients with diabetes mellitus, which is characterized by reduced bone mineral density, destruction of bone microstructure and increased risk of fracture. This condition not only increases the burden of living for patients, but also significantly affects quality of life and puts a heavy strain on the healthcare system. As the prevalence of diabetes mellitus continues to rise globally, the need for DOP prevention and treatment is becoming more urgent. Traditional Chinese medicine (TCM) has unique advantages in regulating chronic diseases and enhancing physical fitness, and is particularly suitable for the management of complex chronic diseases. TCM has shown good efficacy in the prevention and treatment of DOP by regulating glucose metabolism, bone metabolism, and the multiple effects of anti-inflammatory, antioxidant and immunomodulation. The study aims to systematically investigate the role and specific mechanisms of TCM in the prevention and treatment of DOP. By summarizing and analyzing the existing clinical and experimental studies, the effect
细胞焦亡被定义为程序性死亡,其特征是细胞肿胀直至细胞膜破裂、细胞内容物释放并激活强烈的炎症反应。糖尿病性骨质疏松症(diabetic osteoporosis,DOP)是糖尿病相关并发症的一种,表现为骨密度降低、骨量减少和骨结构异常,显著增加了骨折风险。越来越多的研究揭示,在DOP中,成骨细胞由于各种因素的影响,释放了如NOD样受体热蛋白结构域蛋白3(NOD like receptor protein structure domain protein 3,NLRP3)和白细胞介素(IL-1β、IL-18)等媒介物,这些媒介物活化既可以导致细胞焦亡,又在破骨细胞过度分化及骨质疏松症发生中扮演着关键角色。本综述旨在总结细胞焦亡在DOP中的研究进展,并探讨其作为一种潜在的治疗靶点的可能性。
