搜索到466篇“ ATN“的相关文章
ATN诊断框架下阿尔茨海默病的PET/MR研究进展
2024年
阿尔茨海默病(Alzheimer's disease,AD)作为导致痴呆的主要原因之一,其早期诊断对于及时干预和减缓疾病进展至关重要。2018年美国国家衰老研究院-阿尔茨海默协会(National Institute of Aging and Alzheimer's Association,NIA-AA)提出了AD的ATN(amyloid/tau/neurodegeneration)诊断标准,获得了临床普遍认可并广泛使用。本文综述了正电子发射断层显像(positron emission tomography,PET)、磁共振成像(magnetic resonance imaging,MRI)以及正电子发射型磁共振成像系统(positron emission tomography-magnetic resonance imaging,PET/MR)在ATN诊断框架下的应用,并探讨多探针多模态PET/MR在AD诊断中的显著优势。以期为学者提供研究和参考的新思路,推动AD患者的PET/MR临床应用,为临床实践提供重要的影像依据。
周妍周琦东尹晨茹毋若琳盖永康苏颖夏晓天
关键词:阿尔茨海默病生物标志物正电子发射断层显像
基于ATN诊断框架下的阿尔茨海默病分子影像探针研究进展
2024年
阿尔茨海默病(AD)是最常见的神经退行性疾病,通常发生于65岁及以上老年人,轻度认知障碍通常是AD的前驱阶段。利用PET/CT技术可以对AD的潜在分子和细胞过程进行活体成像。基于ATN框架下的β淀粉样蛋白PET、tau PET和FDG PET多探针显像可以表征AD的核心神经病理特征。最近相关研究开发并应用多种新型PET示踪剂,以深入探查AD病理生理功能障碍及内环境改变。本综述总结ATN框架下β淀粉样蛋白、tau蛋白、FDG及神经炎症PET探针在AD研究中的最新进展。
朱泽华朱星星谢强汪世存潘博
关键词:阿尔茨海默病分子成像轻度认知障碍放射性示踪剂
基于ATN分级系统分析高度近视患者中近视性黄斑病变致盲和视力损伤情况以及相关危险因素
2024年
目的基于ATN分级系统分析高度近视患者中近视性黄斑病变致盲和视力损伤情况以及相关危险因素。方法回顾性病例对照研究。收集2022年1月至2023年9月在成都普瑞眼科医院眼底病门诊就诊的642例(642眼)成人高度近视患者的临床资料进行分析。对所有患者均进行全面的眼科检查,并根据ATN分级系统对高度近视患者近视性黄斑病变进行诊断和分级。采用WHO关于盲和视力损伤的诊断标准,将患者分为盲或视力损伤组和无或轻度视力损伤组。采用多因素Logistic回归分析高度近视患者盲或视力损伤的危险因素。结果642眼中,患近视性黄斑病变者共355眼(55.30%);其中,近视萎缩性病变(A2及以上)、近视牵拉性病变和近视新生血管性病变分别有330眼(51.40%)、137眼(21.34%)和82眼(12.77%)。盲眼占比为2.02%(95%CI:0.93%~3.11%),视力损伤眼占比为8.41%(95%CI:6.26%~10.56%)。多因素Logistic回归分析结果显示年龄较大、眼轴长度较长、近视萎缩性病变分级较高是高度近视患者发生盲或视力损伤的独立危险因素(均为P<0.05)。结论ATN分级系统能够全面地反映近视性黄斑病变患者病情严重程度及视力受损状况。年龄较大、眼轴长度较长、近视萎缩性病变分级较高是高度近视患者发生盲或视力损伤的独立危险因素。
刘兴亮古世才艾碧君董晓云李晓玲
关键词:高度近视视力损伤
ATN-161 alleviates caerulein-induced pancreatitis
2024年
Pancreatitis is a common gastrointestinal disorder that causes hospitalization with significant morbidity and mortality.The mechanistic pathophysiology of pancreatitis is complicated,limiting the discovery of pharmacological intervention methods.Here,we show that the administration of ATN-161,an antagonist of Integrin-a5,significantly mitigates the pathological condition of acute pancreatitis induced by caerulein.We find that CK19-positive pancreatic ductal cells align parallel to blood vessels in the pancreas.In the caerulein-induced acute pancreatitis model,the newly emergent CK19-positive cells are highly vascularized,with a significant increase in vascular density and endothelial cell number.Single-cell RNA sequencing analysis shows that ductal and endothelial cells are intimate interacting partners,suggesting the existence of a ductal-endothelial interface in the pancreas.Pancreatitis dramatically reduces the crosstalk in the ductal-endothelial interface but promotes the Spp-1/Integrin-a5 signaling.Blocking this signaling with ATN-161 significantly reduces acinar-to-ductal metaplasia,pathological angiogenesis,and restores other abnormal defects induced by caerulein.Our work reveals the therapeutic potential of ATN-161 as an uncharacterized pharmacological method to alleviate the symptoms of pancreatitis.
Rong-rong GaoLan-yue MaJian-wei ChenYu-xiang WangYu-yan LiZi-yuan ZhouZhao-hua DengJing ZhongYa-hai ShuYang LiuQi Chen
关键词:PANCREATITISANGIOGENESIS
靶向ATN1 mRNA或pre-mRNA的反义寡核苷酸
本说明书中,提供反义寡核苷酸或其药物上可接受的盐或者它们的水合物,其由15~22个核苷酸构成且与包含序列号471的碱基序列的特定靶区域中的至少15个连续的碱基的核酸互补。
河野孝男小手俊明千叶明咲小野寺理加藤泰介广川祥子
阿霉素和ATN161双载脂质体用于靶向协同治疗肺癌的研究
肺癌是全球癌症死亡的主要原因。目前,肺癌的常见治疗方法是化疗,但长期使用化学药物会诱发癌细胞耐药性。另外,化学药物具有癌症杀伤效应但不具备抑制癌症细胞转移的能力。研究发现,肿瘤起始细胞(Tumorinitiatingce...
史佳楠
关键词:肺癌脂质体抗肿瘤药物靶向治疗
ATN1基因新发变异相关神经发育障碍(附1例报告及文献复习)
2023年
目的探讨ATN1基因变异相关神经发育障碍患儿的临床表型、基因特征和诊治方法。方法回顾性分析1例确诊ATN1基因第7号外显子新发突变相关的先天性肌张力减退、癫间、发育迟缓和手指异常(CHEDDA)患儿的临床表现及辅助检查特点,结合复习国内外相关文献进行分析。结果患儿男性,5岁。以癫间发作为主要症状,伴全面性发育迟缓,尤以语言障碍明显,肌张力减低,视频脑电图示典型癫间样放电,头颅MRI示双侧侧脑室稍增大,基因检测证实ATN1基因第7号外显子新发杂合突变(c.3188_3193dup,p.L1063_H1064 dup),确诊为ATN1基因变异相关神经发育障碍CHEDDA。予左乙拉西坦抗癫间治疗及综合康复训练。随访1年余,患儿精神运动发育较前进步,期间11个月无发作,2022年7月又发作2次,左乙拉西坦加量后随访1月余未见发作。结论常染色体显性遗传病CHEDDA是一种非进行性神经病,可因ATN1基因第7号外显子新发突变导致,临床表型缺乏特异性,目前尚无统一的临床诊断标准,对有提示性临床表型患者,尽早完善基因检测,明确诊断以早期给予干预措施。
仇莉汤继宏肖潇张兵兵邢玉娇
关键词:发育迟缓神经发育障碍
Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints被引量:2
2023年
Background Gaining more information about the reciprocal associations between different biomarkers within the ATN(Amyloid/Tau/Neurodegeneration)framework across the Alzheimer’s disease(AD)spectrum is clinically relevant.We aimed to conduct a comprehensive head-to-head comparison of plasma and positron emission tomography(PET)ATN biomarkers in subjects with cognitive complaints.Methods A hospital-based cohort of subjects with cognitive complaints with a concurrent blood draw and ATN PET imaging(18F-florbetapir for A,18F-Florzolotau for T,and 18F-fluorodeoxyglucose[18F-FDG]for N)was enrolled(n=137).Theβ-amyloid(Aβ)status(positive versus negative)and the severity of cognitive impairment served as the main outcome measures for assessing biomarker performances.Results Plasma phosphorylated tau 181(p-tau181)level was found to be associated with PET imaging of ATN biomarkers in the entire cohort.Plasma p-tau181 level and PET standardized uptake value ratios of AT biomarkers showed a similarly excellent diagnostic performance for distinguishing between Aβ+and Aβ−subjects.An increased tau burden and glucose hypometabolism were significantly associated with the severity of cognitive impairment in Aβ+subjects.Additionally,glucose hypometabolism-along with elevated plasma neurofilament light chain level-was related to more severe cognitive impairment in Aβ−subjects.Conclusion Plasma p-tau181,as well as 18F-florbetapir and 18F-Florzolotau PET imaging can be considered as interchangeable biomarkers in the assessment of Aβstatus in symptomatic stages of AD.18F-Florzolotau and 18F-FDG PET imaging could serve as biomarkers for the severity of cognitive impairment.Our findings have implications for establishing a roadmap to identifying the most suitable ATN biomarkers for clinical use.
Jiaying LuXiaoxi MaHuiwei ZhangZhenxu XiaoMing LiJie WuZizhao JuLi ChenLi ZhengJingjie GeXiaoniu LiangWeiqi BaoPing WuDing DingTzu-Chen YenYihui GuanChuantao ZuoQianhua Zhao
关键词:PLASMA
基于ATN框架的阿尔茨海默病影像基因组学研究
阿尔茨海默病(Alzheimer’s disease,AD)是老年人群常见的神经退行性疾病,其早期诊断具有重要临床价值。ATN(amyloid[A],tau[T],neurodegeneration[N])框架是临床公认...
李岚岚
关键词:阿尔茨海默病
Infuence of Gender on Tau Precipitation in Alzheimer’s Disease According to ATN Research Framework被引量:3
2023年
Tau proteins accumulation and their spreading pattern were afected by gender in cognitive impairment patients,especially in the progression of Alzheimer’s disease(AD).However,it was unclear whether the gender efects for tau deposition infuenced by amyloid deposition.The aim of this study was to investigate gender diferences for tau depositions in Aβpositive(A^(+))subjects.In this study,tau and amyloid positron emission tomography images,structural magnetic resonance imaging images,and demographic information were collected from 179 subjects in Alzheimer’s Disease Neuroimaging Initiative(ADNI)database and 63 subjects from Huashan Hospital.Subjects were classifed as T^(+)or T^(-)according to the presence or absence of tau(T)biomarkers.We used two-sample t test and one-way analysis of variance test to analyze the efect of gender with adjusting for age,years of education,and Minimum Mental State Examination.In the ADNI cohort,we found diferences in Tau deposition in fusiform gyrus,inferior temporal gyrus,middle temporal gyrus and parahippocampal gyrus between the female T^(+)(FT^(+))and male T^(+)(MT^(+))groups(p<0.05).Tau deposition did not difer signifcantly between female T^(-)(FT^(-))and male T^(-)(MT^(-))subjects(p>0.05).In the Huashan Hospital cohort,there was no diference in Tau deposition between FT^(+)and MT^(+)(p>0.05).The results show that tau depositions signifcantly increased in females in above brain regions.Our fndings suggest that tau deposition is infuenced by gender in the A+subjects.This result has important clinical implications for the development of gender-guided early interventions for patients with both Tau and Amyloid depositions.
Ying ZhangJiaying LuMin WangChuantao ZuoJiehui Jiang
关键词:GENDER

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