Difluoromethylene group(CF2) can act as an isopolar-isosteric substitute for oxygen,and replacement of the pho...
Zhang Feng,Fei Chen,and Xingang Zhang~* Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China
An effective method for Pd-catalyzed cross-coupling between polyfluoroarenes and cyclic vinyl triflates has been developed.This protocol provides a useful and facile access to polyfluoroarylated cyclic alkenes that are difficult to prepare otherwise.The advantages of this method are its high efficiency and operational simplicity.
An effective and facile method for preparation of partially fluorinated aromatics via Nickel catalyzed, chelation-assisted ortho selective hydrodefluorination of polyfluoroames with triethylsilane has been developed, in which N-containing heterocycles were used as directing groups. The advantage of this protocol is its simple catalytic system with use of inexpensive and readily available NiCl2·6H2O as a catalyst.
