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国家自然科学基金(30570531)

作品数:7 被引量:46H指数:3
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MR磁敏感成像技术的原理及其在脑部疾病的应用
2010年
磁敏感成像技术是近几年发展起来的MR新技术,是一项可以反映组织磁敏感属性的新的对比度增强技术,提供了T1WI、T2WI、质子密度以及扩散程度之外的另一种对比度,包含脂肪、铁、钙、去氧血红蛋白等物质的组织磁敏感属性与邻近的背景组织明显不同,
朱文珍王承缘夏黎明漆剑频
关键词:成像技术磁敏感脑部疾病MRT1WI
MR磁敏感成像技术的原理及其在脑部疾病的应用被引量:9
2009年
朱文珍王承缘夏黎明漆剑频
关键词:成像技术磁敏感脑部疾病MRT1WIT2WI
RSNA2012中枢神经系统影像学被引量:1
2013年
RSNA2012报道的拓展MRI新技术及数据分析方法主要包括酰胺质子转移(APT)、扩散峰度成像(DKI)、多b值非高斯扩散、动脉自旋标记(ASL)、直方图分析法、自动化脑分割SyMRI及大角度高分辨力扩散成像(HARD)I等,在中枢神经系统疾病的应用研究主要包括:①胶质瘤术前分级、肿瘤分子生物学行为评估及鉴别肿瘤真性和假性进展;②脑卒中缺血性损伤的PH值变化、非高斯分布扩散变化、血流灌注信息、界定缺血半暗带以及急性卒中运动障碍恢复与皮质脊髓束的关系;③自动化脑分割SyMRI精确定量多发性硬化脑组织体积;④4D相位对比成像探索特发性脊髓空洞症发病机制及脑脊液动力学变化;⑥HARDI脑白质纤维束追踪技术可明显提高白质分割的精确性。另一亮点是关于阿尔茨海默病认知功能研究。
穆可涛覃媛媛张顺江晶晶胡杉石晶晶朱文珍
关键词:脑肿瘤脑血管病神经系统变性疾病动脉自旋标记
阿尔茨海默病的MRI研究进展被引量:3
2007年
占传家朱文珍漆剑频
关键词:阿尔茨海默病MRIMRSDTIFMRI
阿尔茨海默病额叶白质损害的DTI与临床执行功能的关系被引量:4
2009年
目的分别应用磁共振扩散张量成像(diffusion tensor imaging,DTI)及额叶功能评定量表(frontal as-sessment battery,FAB)评价阿尔茨海默病(Alzheimer disease,AD)患者额叶白质损害与执行功能,并对两者的关系进行研究。方法对15例AD组和15例对照组应用FAB测得评分,并且进行DTI扫描,测量额叶白质的部分各向异性(fractional anisotropy,FA)和平均扩散系数(average diffusion coefficient,ADC)值,对两组额叶白质区域的FA值和ADC值及FAB评分进行比较,并评价额叶白质的FA值和ADC值与临床执行功能评分之间的相关关系。结果AD患者FAB值及额叶白质FA值均较对照组显著降低,额叶白质FA值与FAB值呈正相关(r=0.678,P=0.003)。结论FAB能够实用且有效的检测AD患者额叶执行功能的改变,FA值可反映AD患者额叶白质受损程度及其与执行功能的关系。
王珲唐荣华朱文珍方思羽占传家胡伟夏友华王建枝
关键词:阿尔茨海默病执行功能障碍磁共振扩散张量成像
Magnetic resonance susceptibility weighted imaging in detecting intracranial calcification and hemorrhage被引量:26
2008年
Background Computed tomography (CT) is better than routine magnetic resonance imaging (MRI) in detecting intracranial calcification. This study aimed to assess the value of MR susceptibility weighted imaging (SWI) in the detection and differentiation of intracranial calcification and hemorrhage. Methods Enrolled in this study were 35 patients including 13 cases of calcification demonstrated by CT and 22 cases of intracerebral hemorrhage. MR sequences used in all the subjects included axial T1WI, T2WI and SWI. The phase shift (PS) of calcification and hemorrhage on SWI was calculated and their signal features on corrected phase images were compared. The sensitivity of T1WI, T2WI and SWI in detecting intracranial calcification and hemorrhage was analyzed statistically. Results The detection rate of SWI for cranial calcification was 98.2%, significantly higher than that of T1WI and T2WI. It was not significantly different from that of CT (P 〉0.05). There were 49 hemorrhagic lesions at different stages detected on SWI, 30 on T2WI and 18 on T1WI. The average PS of calcification and hemorrhage was +0.734±0.073 and -0.112±0.032 respectively (P 〈0.05). The PS of calcification was positive and presented as a high signal or the mixed signal dominated by a high signal on the corrected phase images, whereas the PS of hemorrhage was negative and presented as a low signal or the mixed signal dominated by a low signal.Conclusions SWI can accurately demonstrate intracranial calcification, not dependant on CT. Being more sensitive than routine MRI in detecting micro-hemorrhage, SWI may play an important role in differentiating cerebral diseases associated with calcification or hemorrhage.
ZHU Wen-zhen QI Jian-pin ZHAN Chuan-jia SHU Hong-ge ZHANG Lin WANG Cheng-yuan XIA Li-ming HU Jun-wu FENG Ding-yi
关键词:HEMORRHAGE
Investigation on Positive Correlation of Increased Brain Iron Deposition with Cognitive Impairment in Alzheimer Disease by Using Quantitative MR R2' Mapping被引量:3
2011年
Brain iron deposition has been proposed to play an important role in the pathophysiology of Alzheimer disease(AD).The aim of this study was to investigate the correlation of brain iron accumulation with the severity of cognitive impairment in patients with AD by using quantitative MR relaxation rate R2' measurements.Fifteen patients with AD,15 age-and sex-matched healthy controls,and 30 healthy volunteers underwent 1.5T MR multi-echo T2 mapping and T2* mapping for the measurement of transverse relaxation rate R2'(R2'=R2*-R2).We statistically analyzed the R2' and iron concentrations of bilateral hippocampus(HP),parietal cortex(PC),frontal white matter(FWM),putamen(PU),caudate nucleus(CN),thalamus(TH),red nucleus(RN),substantia nigra(SN),and dentate nucleus(DN) of the cerebellum for the correlation with the severity of dementia.Two-tailed t-test,Student-Newman-Keuls test(ANOVA) and linear correlation test were used for statistical analysis.In 30 healthy volunteers,the R2' values of bilateral SN,RN,PU,CN,globus pallidus(GP),TH,and FWM were measured.The correlation with the postmortem iron concentration in normal adults was analyzed in order to establish a formula on the relationship between regional R2' and brain iron concentration.The iron concentration of regions of interest(ROI) in AD patients and controls was calculated by this formula and its correlation with the severity of AD was analyzed.Regional R2' was positively correlated with regional brain iron concentration in normal adults(r=0.977,P0.01).Iron concentrations in bilateral HP,PC,PU,CN,and DN of patients with AD were significantly higher than those of the controls(P0.05);Moreover,the brain iron concentrations,especially in parietal cortex and hippocampus at the early stage of AD,were positively correlated with the severity of patients' cognitive impairment(P0.05).The higher the R2' and iron concentrations were,the more severe the cognitive impairment was.Regional R2
覃媛媛朱文珍占传家赵凌云王建枝田青王伟
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