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作品数:6 被引量:74H指数:4
相关作者:王拥军杨燕萍王成龙常君丽郭梦瑶更多>>
相关机构:上海中医药大学滨州医学院更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
相关领域:医药卫生更多>>

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Polyphyllinl,A Novel Natural Proteasome Inhibitor,Suppresses Human Osteosarcoma Growth by Targeting NF-κB and UPR/ER Stress
<正>Osteosarcoma is a most common highly malignant bone tumor in children and adolescents.The use of natural pr...
Yanping YangHongshen WangJunli ChangYouji JiaChenglong WangYongjian ZhaoShufen LiuXianyang WangSheng LuQi ShiQinghua ZengJacquelyn ZimmermanYongjun Wang
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中医药防治恶性肿瘤化疗后骨髓抑制的研究进展被引量:25
2015年
从中医学病因病机、治则治法和方药应用等方面探讨中医药抗肿瘤化疗后骨髓抑制的作用和机制。我们以中医药防治骨髓抑制血三系下降的方剂为主对其研究进展进行综述,为临床积极防治骨髓抑制提供参考和指导,以满足临床研究的多元化需求。
杨志烈王成龙王拥军杨燕萍
关键词:中医药化疗骨髓抑制
骨肉瘤免疫治疗的研究现状被引量:7
2017年
骨肉瘤也称为成骨肉瘤,是青少年及儿童最常见的恶性骨肿瘤,是一种复发率极高,且极难治愈的原发性恶性肿瘤。现如今,随着各类医学技术的发展,骨肉瘤的诊治得到了很大的提高,但是由于骨肉瘤本身恶性度高、生长迅速、早期转移且治疗后极易复发,骨肉瘤的治疗和治疗后控制依然是临床上的一大难题。因此找到一种能够更大程度地减少患者痛苦、降低人体损伤的治疗方法迫在眉睫,而免疫治疗为骨肉瘤的生物学治疗提供了一种崭新的治疗方向。因此,现对骨肉瘤免疫治疗的研究现状作一综述,望为骨肉瘤的研究及临床进展提供一定的方向。
李奕緜常君丽施杞王拥军杨燕萍
关键词:骨肉瘤免疫治疗
现代医学治疗骨肉瘤现状分析及展望被引量:20
2017年
骨肉瘤(Osteosarcoma)。又称成骨肉瘤,是临床上常见的原发性恶性、成骨性肿瘤。该病好发于15~25岁青少年,主要发生在长骨干骺端,如股骨远端,肱骨近端是最易发生病变的部位。虽然受种族、地域等因素影响,但全球男性的发病率较女性高,有研究表明,男性与女性的发病率之比约为1.28:1,骨肉瘤的另一发病高峰人群为年龄〉60岁的老年人,在这年龄段中,依旧是男性的发病率较高,男性与女性的发病率之比约为1.01。
郭梦瑶王拥军杨燕萍
关键词:成骨肉瘤原发性恶性成骨性肿瘤长骨干骺端股骨远端
From Osteoblast to Osteoclast: New Insights of Yin-Yang Theory in Bone Remodeling被引量:1
2015年
Yin-Yang theory plays critical role in traditional Chinese medicine(TCM) science. However, there are many competing interpretations of YinYang theory in the context with the development in biology, and no consensus has been established. Here we first propose that osteoblast should be regarded as Yin, while osteoclast should be considered as Yang in bone remodeling compartment(BRC). Our conceptions are consistent with the following key findings: 1)osteoblast and osteoclast both derive from the embryonic ectoderm; 2)osteoblast and osteoclast work collaboratively in BRC to maintain bone homeostasis; 3)the activities of osteoblast and osteoclast are coupled to remain dynamic balance;4)osteoblast and osteoclast exert their function in ceaseless successions. Moreover, we argue that Yin-Yang relationships exist between osteoblast and osteoclast: osteoblast secretes the receptor activator for nuclear factor-κB ligand(RANKL) and the monocyte/macrophage colony-stimulating factor(M-CSF) and osteoprotegerin(OPG) to positively or negatively regulate osteoclast differentiation and function.Meanwile, osteoclast and bone resorption in turn release cytokines, such as transforming growth factor-β(TGF-β), insulin-like growth factor-1(IGF-1) from bone matrix, to regulate osteoblast differentiation and function. Next, the unlimited division of Yin-Yang can be applied to divide sublevel of Yin-Yang inside osteoblast or osteoclast. Finally, Yin-Yang relationship of osteoblast and osteoclast is relative. Therefore, we come into the conclusion that the relationships between osteoblast and osteoclast as established in contemporary biology reflect the classic Yin-Yang in bone remodeling. The new Yin-Yang concepts of osteoblast and osteoclast may strengthen basic theory and clinical practice in TCM.
Dong-Feng ZhaoCheng-Long WangYong-Jian ZhaoZhi-Lie YangQi ShiXu FengYan-Ping YangYong-Jun Wang
关键词:OSTEOBLASTOSTEOCLAST
New Insights into the Molecular Basis of Kidney Governing Bone Theory被引量:2
2015年
Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney prescriptions/herbs are widely used in Traditional Chinese Medicine(TCM). However, the exact biological basis of kidney governing bone theory in the context of new advances in biology is still not fully established. In this paper, the content of kidney governing bone theory in biology has been fully demonstrated from different aspects. We first propose that bone and kidney mutually affect each other in pathology and physiology, particularly through homeostasis of calcium, phosphorus and fibroblast growth factor-23(FGF-23). Next, we identify that tonifying kidney prescriptions/herbs exert bone protective effects, thus treating osteoporosis by regulating bone formation and bone resorption.Furthermore, the exact molecular mechanisms of tonifying kidney prescriptions, herbs and their effective components in treating osteoporosis have been systematically reviewed. Finally, we come into the conclusion that kidney regulating bone mineral homeostasis, bone protective effects of tonifying kidney herbs and regulatory effects on bone homeostasis are all the manifestations of kidney governing bone theory.Therefore, the new insights into kidney governing bone theory in biology will promote the development of clinical practices, and drugs discovery in treating osteoporosis.
Dong-feng ZhaoYong-jian ZhaoCheng-long WangYan-ping YangYong-jun Wang
关键词:OSTEOCLASTOSTEOBLAST
淫羊藿苷对环磷酰胺化疗导致小鼠骨髓间充质干细胞成骨分化障碍的保护作用被引量:20
2016年
背景:化疗引发骨质疏松已成为严重影响骨骼系统的毒副作用之一,淫羊藿苷具有很强的抗骨质疏松活性,可能对化疗引发的骨质疏松具有保护作用。目的:观察淫羊藿苷对环磷酰胺导致小鼠骨髓间充质干细胞成骨分化障碍的保护作用及机制研究。方法:以MTT法检测结合碱性磷酸酶染色,确定淫羊藿苷对环磷酰胺导致的骨髓间充质干细胞成骨分化障碍的最佳保护剂量。采用RT-PCR法测定淫羊藿苷最佳剂量干预下不同时间点成骨转录特异性因子ALP、OC、Runx2及Wnt/β-catenin信号通路相关基因β-catenin、C-Myc、Cyclin D1 m RNA的表达;Western blot测定最佳剂量情况下淫羊藿苷调节骨髓间充质干细胞成骨特异性转录因子Runx2及Wnt/β-catenin信号通路相关基因Activeβ-catenin、C-Myc、Cyclin D1蛋白的表达。结果与结论:1与正常对照组比较,环磷酰胺组细胞活力及碱性磷酸酶染色减弱,相比于环磷酰胺组,淫羊藿苷各浓度组细胞活力无明显差异;碱性磷酸酶染色显示100μmol/L淫羊藿苷对骨髓间充质干细胞成骨分化障碍的保护作用最佳。2与正常对照组比较,环磷酰胺组降低了成骨指标ALP、OC、Runx2m RNA和Runx2蛋白表达,减弱了Wnt/β-catenin信号通路相关基因β-catenin、Cyclin D1 m RNA及Activeβ-catenin、Cyclin D1、c-myc蛋白的表达水平,增加了Wnt/β-catenin信号通路抑制蛋白DKK1表达;与环磷酰胺组比较,100μmol/L淫羊藿苷能促进各成骨相关指标及Wnt/β-catenin信号通路相关基因的m RNA和蛋白水平,并降低DKK1蛋白表达。3结果表明,环磷酰胺能导致小鼠骨髓间充质干细胞成骨分化障碍,淫羊藿苷对其具有保护作用,且100μmol/L浓度的淫羊藿苷干预效果最佳,而这种保护作用可能与淫羊藿苷激活Wnt/β-catenin信号通路有关。
杨志烈王成龙赵东峰常君丽杨成杨燕萍王拥军
关键词:干细胞骨髓干细胞环磷酰胺骨髓间充质干细胞成骨分化淫羊藿苷
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