The relationship between the properties of PCBs and the behavior of soil and sediment is reviewed. The sorp-tion phenomena of PCBs in the environment are described with different models. The research progress on the sorption mechanisms is also discussed.
Holographic QSAR model is constructed to predict relative binding affinities of estradiol derivatives with lamb uterine estrogen receptor. The method does not require the generation of three-dimensional structure of the compounds. The factors that influence the quality of QSAR model are discussed. The result indicates that the model has good predictability and yields a high q2LOO value of 0.897. Compared to other QSAR methods, the HQSAR technique is suitable for use in screening large database of chemicals.
CUI Shihai, LIU Shushen, WANG Xiaodong & WANG Liansheng State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210093, China
