A concise route for the total syntheses of benzopranylchalcones from 2,4,6-trihydroxyacetophone(3) and citral(8), by means of cyclization, methoxy-protection and aldol-condensation is described. Two benzopranylchalcones, Boesenbergin B(1) and Boesenbergin A(2) were synthesized from 2,4,6-(trihydroxyacetophone)(3), citral(8) and benzaldehyde(9) via the route. The total yields of compounds 1 and 2 were 26% and 11%, respectively. In the cyclization step, the yields of key intermediates 4 and 7 were 40% and 42%, respectively.
＜正＞ The geranylated chalcone 1,3′-geranyl-2′,3,4,4′-tetvahydroxychalcone with high 5α-reductase inhibitory pro...
LIU, Hong-Xing HUANG, Chu-Sheng CHEN, Xi-Hui ZHU, Yan-Yun(Applied Chemical Institute of Guangxi Teachers'' College, Nanning 530001) (College of Chemistry and Chemical Engineering, Guangxi University, Nanging 530004)
