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国家自然科学基金(81271786)

作品数:6 被引量:7H指数:2
相关作者:刘慧迪刘树林王洪月李婷高杉更多>>
相关机构:哈尔滨医科大学齐齐哈尔市第一医院更多>>
发文基金:国家自然科学基金国家留学基金中国博士后科学基金更多>>
相关领域:医药卫生生物学更多>>

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Spontaneous modulation of a dynamic balance between bacterial genomic stability and mutability: roles and molecular mechanisms of the genetic switch被引量:1
2014年
Bacteria need a high degree of genetic stability to maintain their species identities over long evolutionary times while retaining some mutability to adapt to the changing environment.It is a long unanswered question that how bacteria reconcile these seemingly contradictory biological properties.We hypothesized that certain mechanisms must maintain a dynamic balance between genetic stability and mutability for the survival and evolution of bacterial species.To identify such mechanisms,we analyzed bacterial genomes,focusing on the Salmonella mismatch repair(MMR)system.We found that the MMR gene mutL functions as a genetic switch through a slipped-strand mispairing mechanism,modulating and maintaining a dynamic balance between genetic stability and mutability during bacterial evolution.This mechanism allows bacteria to maintain their phylogenetic status,while also adapting to changing environments by acquiring novel traits.In this review,we outline the history of research into this genetic switch,from its discovery to the latest findings,and discuss its potential roles in the genomic evolution of bacteria.
TANG LeLIU RuoWeiJIN GangZHAO ErYingLIU GuiRongLIU ShuLin
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