The problem of active structural acoustic control in an enclosure using radiation mode is investigated. The response of the coupled enclosure is derived in terms of radiation modes. The potential energy in the enclosure can be decomposed into independent parts and the radiation modes contribute to potential energy independently. The control strategy for minimizing first G radiation modes with large radiation efficiency is proposed, and the optimal model of control forces is presented. Finally, a numerical simulation for minimizing sound transmission into a rectangular enclosure using the proposed method is conducted. Simulation results indicate that one control force can control one radiation mode and controlling the first four-order radiation modes with four control forces can achieve significant potential energy reduction at the low frequency range.