＜正＞3-Aryl-4（3H）-quinazolinones have exhibited a variety of interesting biological activities such as antiinfla...
CAO, Sheng-Li ZHANG, Mei FENG, Yu-Ping GAO, Hong-He ZHEN, Bo-Ming (Department of Chemistry, Capital Normal University, Beijing 100037) (Key Laboratory of Organic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084)
Classical antifolates containing L-glutamic acid moiety in molecule have shortcomings such as drug resistance which is originated from the defective cell transport by mutation, and toxicity to the host which is due to unnecessarily long retention inside normal cells.[1] One strategy to overcome these shortcomings is to design nonclassical lipophilic inhibitors of folate requiring enzymes by deleting or modifying L-glutamic acid component from the folate analogues.……
＜正＞In our research program on 4（3H）-quinazolinone derivatives acting as possible nonclassical antifolates agen...
CAO, Sheng-Li FENG, Yu-Ping YANG, Jie JIANG, Yu-Yang WANG, Yue XU, Meng (Department of Chemistry, Capital Normal University, Beijing 100037) (Department of Chemistry, Tsinghua University, Beijing 100084) (Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055)
