Hyperuricemia(HUA)is a risk factor for chronic kidney disease(CKD).The relationship between HUA and white blood cell(WBC)count remains unknown.A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014.CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m2).HUA was defined as serum uric acid>420µmol/L in men and>360µmol/L in women.This study included 1024 participants.The prevalence of HUA was 17.77%.Patients with HUA were more likely to have higher levels of WBC count,which was positively associated with HUA prevalence.This association was also observed in participants without CKD,diabetes mellitus,hyperlipidemia,or obesity.Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants.Compared with participants without HUA,inflammatory factors such as high-sensitivity C-reactive protein,tumor necrosis factor-α,and interleukin 6 increased in participants with HUA.Hence,WBC count is positively associated with HUA,and this association is independent of conventional risk factors for CKD.
目的本研究的目的是研究不同的营养评估方法与维持性血液透析患者的预后的关系。方法对我院血液透析中心的83名患者进行营养评估,包括主观综合性营养评估(subjective global assessment,SGA)、营养不良-炎症评分(malnutrition inflammation score,MIS)和微型营养评定简表(mini nutrition assessment short form,MNA-SF)。同时收集基本资料、辅助检查结果。随访48月(40±13月),采用Kaplan-Meier以及Cox回归分析比较不同营养评估方法与患者全因死亡风险的差别。结果 Kaplan-Meier分析提示:SGA<25分患者的死亡风险较SGA≥25分患者高(P<0.05),MIS>10分组比MIS≤10分死亡风险高(P>0.05)。以MNA-SF分组,MNA-SF≥11分死亡风险低于NA-SF<11分(P>0.05)。多因素Cox回归分析提示,SGA及MIS不同分组仍然与维持性血液透析患者不同的全因死亡风险有关(P<0.05)。结论不同营养评估方法对于维持性血液透析患者长期生存的预测能力不同,SGA法以及MIS法所评价的营养状况与维持性血液透析患者长期的全因死亡风险有较好相关性。
