＜正＞Designing new multicomponent reactions（MCRs） as well as improving known MCRs constitute a research area of ...
Yijun Duan,~a Xue Wang,~a Min Zhang,~a Liping Song~(*a,b) a Department of Chemistry,School of Science,Shanghai University, b Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,
Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0 ℃ to give 2,6-dimethyl-3,5-bis（4,4,4-trifluoro-1,3-oxo-butyl）-pyridine （2a） in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a--5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[（3-aryl-5-trifluoromethyl）-isoxazol-4-carbonyl]-pyridine derivatives 6a=6i.
Yindi YangMin ZhangYiwen ZhuLi ZhangQiqiang XieLiping SongHongmei Deng
