Introduction Liver cirrhosis generally occurs with the hemodynamic changes during the portal vein hypertension and finally leads to the atrophy of the right lobe of the liver and hepatic failure[1].According to the hemodynamic changes,a hypothesis has been proposed that the liver volume is related to the istribution of blood from the splenic vein（SV）that involves nutrition from spleen and pancreas[2,3].The objective of the present paper is to simulate the blood flow in real models of portal vein hypertension and validate the hypothesis using computational fluid dynamics（CFD）method.Methods This study includes 2 patients with liver cirrhosis and a set of 4 normal subjects.
