The title compound(S)-N-(2-oxoazepan-3-yl)biphenyl-4-carboxamide(C19H20N2O2, Mr = 308.37) was synthesized by the reaction of(S)-α-amino-∑-caprolactam with 4-phenyl-benzoyl chloride. Its chemical structure was determined by 1H NMR, 13 C NMR, H RMS and X-ray single-crystal diffraction. The crystal belongs to the triclinic system, space group P1 with a = 8.2650(17), b = 13.774(3), c = 15.109(3) ?, β = 90.20(3)o, V = 1645.6(6) ?3, Z = 4, Dc = 1.245 g/cm3, μ = 0.081 mm-1, F(000) = 656, R = 0.0756 and w R = 0.1491 for 5964 observed reflections with I > 2σ(I). The title compound was also used to prepare polyamide.
In this study,etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system(MFS),providing the resulting ethers in high yield with fewer side effects.Meanwhile,this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides,giving moderate yields.
