Plasma lipid abnormalities are implicated in the pathogenic process of type 2 diabetes.The IDE-KIF11-HHEX gene cluster on chromosome 10q23.33 has been identified as a susceptibility locus for type 2 diabetes.We hypothesized that genetic variants at 10q23.33 may be associated with plasma lipid concentrations.Seven tagging single nucleotide polymorphisms(SNPs:rs7923837,rs2488075,rs947591,rs11187146,rs5015480,rs4646957 and rs1111875) at 10q23.33 were genotyped in 3,281 subjects from a Han Chinese population,using the TaqMan OpenArray and Sequenom MassARRAY platforms.Multiple linear regression analyses showed that SNP rs7923837 in the 3'-flanking region of HHEX was significantly associated with triglyceride levels(P = 0.019,0.031 mmol/L average decrease per minor G allele) and that rs2488075 and rs947591 in the downstream region of HHEX were significantly associated with total cholesterol levels(P = 0.041,0.058 mmol/L average decrease per minor C allele and P = 0.018,0.063 mmol/L average decrease per minor A allele,respectively).However,the other four SNPs(rs11187146,rs5015480,rs4646957 and rs1111875) were not significantly associated with any plasma lipid concentrations in this Chinese population.Our data suggest that genetic variants in the IDE-KIF11-HHEX gene cluster at 10q23.33 may partially explain the variation of plasma lipid levels in the Han Chinese population.Further studies are required to confirm these findings in other populations.
目的了解常州市武进区60岁及以上老年人高脂血症及其流行病学分布特征。方法利用整群随机抽样的方法,抽取常州市武进区60岁及以上老年人群4 967人,对所有样本人群进行流行病学调查及相关生化指标检查。结果常州市武进区60岁及以上人群高脂血症患病率为25.91%,标化率为25.93%,女性患病率(29.56%)高于男性(20.84%)(P<0.001),且高脂血症的患病率随年龄增高而下降(P=0.004);其中单纯性高胆固醇血症、单纯性高甘油三酯血症、单纯性低高密度脂蛋白胆固醇血症和混合型高脂血症的患病率分别为4.59%、12.25%、7.13%和1.94%。多因素Logistic分析显示,女性、低年龄组、有高血压史、体重指数(body mass index,BMI)和空腹血糖升高为高脂血症的危险因素。结论常州市武进区60岁及以上老年人群高脂血症患病率较高,应该加强健康教育,开展危险因素的干预,降低慢性病对人群健康的危害。
