In the post-genomic biology era,the reconstruction of gene regulatory networks from microarray gene expression data is very important to understand the underlying biological system,and it has been a challenging task in bioinformatics.The Bayesian network model has been used in reconstructing the gene regulatory network for its advantages,but how to determine the network structure and parameters is still important to be explored.This paper proposes a two-stage structure learning algorithm which integrates immune evolution algorithm to build a Bayesian network.The new algorithm is evaluated with the use of both simulated and yeast cell cycle data.The experimental results indicate that the proposed algorithm can find many of the known real regulatory relationships from literature and predict the others unknown with high validity and accuracy.
Gui-xia Liu, Wei Feng, Han Wang, Lei Liu, Chun-guang ZhouCollege of Computer Science and Technology, Jilin University, Changchun 130012,P.R. China
提出了一种基于网格距离的融合式聚类算法(Agglomerative Clustering algorithm based on Grid Distance,ACGD)。为规模不同的数据集分别设计了初始球状网格和初始矩形网格,并以此作为合并过程的起点。基于随机映射思想设计了网格之间的距离定义并以此完成聚类任务。ACGD的参数以自适应学习策略确定。真实数据集上的实验表明,ACGD具有良好聚类效果,具有比同类算法更高的效率和算法鲁棒性。
