A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.
Jian Hong Wang Jun Jun Zhou Song Qing Xie Qian Li Jin Zhao Chao Jie Wang
We reported four fluorescent chemosensors containing tryptophan units.The fluorescence spectrum titration experiments suggest that chemosensors 1,2,3 and 4 are highly selective for Cu2＋ and Fe3＋ over Li＋,Na＋,K＋,Co2＋,Zn2＋,Ni2＋,Hg2＋ and Cr3＋ via forming complexes with Cu2＋ or Fe3＋,which is confirmed by dramatical quench of fluoreseence in aqueous solution at pH 7.4,thus making all the chemosensors suitable for Cu2＋ and Fe3＋ fluorescent sensors.
CHENG Peng-feiXU Kuo-xiYAO Wen-yongKONG Hua-jieKOU LiMA Xiao-danWANG Chao-jie
