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国家重点基础研究发展计划(2012FY110300)

作品数:6 被引量:26H指数:3
相关作者:付瑶王赟杨永平杨雪飞更多>>
相关机构:中国科学院更多>>
发文基金:国家重点基础研究发展计划国家自然科学基金教育部留学回国人员科研启动基金更多>>
相关领域:医药卫生理学生物学更多>>

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Chemical constituents from the aerial parts of Euphorbia sikkimensis and their bioactivities被引量:4
2013年
Phytochemical investigation of the aerial parts of Euphorbia sikkimensis led to the isolation of one new diterpenoids,named sikkimenoid E(1),together with thirteen other known compounds(2-14).Their structures were established by means of spectroscopic methods.Compound 2 was identified to be a trinortriterpenoid,and derived for the first time from a natural source.In this paper we reveal for the first time its comprehensive spectral data and NMR spectral assignment.Compound 4 showed anti-angiogenic activity with an IC_(50) value of 5.66μM in a zebrafish model,and compounds 5 and 6 exhibited cytotoxicity toward A549 cell line with IC_(50) values of 12.12 and 6.45μM,respectively.
Da-Song YANGWei-Bing PENGZi-Lei LIXue WANGJian-Guo WEIKe-Chun LIUYong-Ping YANGXiao-Li LI
关键词:BIOACTIVITIES
Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity被引量:1
2015年
Three new minor prenylated flavonoids,named macadenanthins A–C(1–3),together with three known ones(4–6),were isolated from the twigs of Macaranga adenantha.Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR,UV and MS.The prenyl moieties in compounds 1–3 were further modified by cyclization and hydroxylation.The new compounds were tested for their cytotoxicity against four cancer cell lines(MCF-7,Hep G2,Hela and P388)and showed IC50 values in the range of 13.76–22.27 lM.
Da-Song YangShuang-Mei WangWei-Bing PengYong-Ping YangKe-Chun LiuXiao-Li LiWei-Lie Xiao
关键词:CYTOTOXICITY
Chemical constituents of Euphorbia tibetica and their biological activities被引量:9
2014年
AIM: To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica. METHOD: Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay. RESULTS: One new compound, methyl 4-epi-shikimate-3-O-gallate(1), together with twenty-three known constituents(2–24) were isolated from the aerial parts of E. tibetica. CONCLUSION: Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5–7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.
YANG Da-SongHE Qiu-XiaYANG Yong-PingLIU Ke-ChunLI Xiao-Li
关键词:EUPHORBIACEAEDITERPENESCYTOTOXICITY
西藏东部牧民对藏药植物山莨菪的传统利用及环境适应意义(英文)
2015年
野生植物资源及相关传统知识是传统人类社会应对自然灾害的重要基础。在西藏东部地区,传统藏药植物山莨菪(Anisodus tanguticus)是当地牧民防御冬季低温灾害对牲畜造成伤害的一种重要的植物资源。本文采用半结构访谈法和参与式观察法,对7个村13个关键信息员,以及2个村以畜牧为主的牧户进行了访谈调查。对牧民秋季收割山莨菪地上枯枝部分以备冬季饲喂家畜作为防御冬季雪灾和冷害等传统知识和实践进行了记载。针对山莨菪含剧毒的问题,牧民采取严格控制采收时间和饲喂对象的方法来解决。当地社区积累了关于山莨菪生长习性、用法、功效等方面较为完整的知识,并通过对其权属进行民间界定,实现了对资源的良性管理。这一案例表明:人类在与自然长期互动的过程中所产生和积累的传统知识能够为其防御自然灾害,降低气候风险起关键性作用。
付瑶王赟杨永平杨雪飞
关键词:传统知识牧民青藏高原饲料植物山莨菪
Chemical Constituents from Hypericum beanii被引量:11
2015年
Objective To study the chemical constituents from the aerial parts of Hypericum beani/. Methods Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results Fifteen compounds were isolated from the aerial parts of H. beanii. Their structures were identified as hyperbeanol E (1), (E)-Iinalool-l-oic acid (2), (4S,5R)-5-(4'-methyl-3'-pentenyl)-4-hydroxy-5-methyl- dihydrofuran-2-one (3), benzoic acid (4), 4-(3-O-3")-3"-methylbutenyl-6-phenyl- pyran-2-one (5), 4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxJn-2(3H)- one (6), isoimperatorin (7), 2,3-dimethoxyxanthone (8), 3,4-dihydroxy-2- methoxyxanthone (9), osajaxanthone (10), nigrolineaxanthone F (1 1), hypercohone G (12), betulinic acid (1 3), oleanolic acid 3.13-caffeate (14), and isoastilbin (1 5). Conclusion Compound 1 is a new menthane monoterpene derivative which owns an extra lactone ring. Compounds 2-7 and 10-1 5 are isolated from genus Hypericum Linn. for the first time and the other compounds are first obtained from the plants in H. beanii.
Da-song YangZi-lei LiYong-ping YangXiao-li LiWei-lie Xiao
关键词:XANTHONE
A New Geranylated 2-Arylbenzofuran from Morus alba被引量:2
2015年
Objective To study the chemical constituents from the root barks of Morus alba. Methods Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results Six compounds were isolated from the root barks of M. alba. The structure of new compound, named as albafuran D(1), was established together with known compounds sanggenon H(2), kuwanon E(3), kuwanon U(4), kuwanon F(5), and benzokuwanon E(6). Conclusion Compound 1 is a new geranylated 2-arylbenzofuran.
Da-song YangZi-lei LiYong-ping YangWei-lie XiaoXiao-li Li
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