Objective: To search for the best therapy for the headache of drug - dependence. Methods: Forty - five cases were randomly divided into a treatment group and a control group. There were 30 cases in the treatment group and 15 cases in the control group. They were treated by acup - mox ther and placebo. Results: In the treatment group, 21 cases were successful and 9cases were failed. In the control group,5 cases were successful and 10 cases were failed.The therapy between the treatment group and the control group has a significant difference in effective rate (0.01 < P<0.05) So, the therapy of the headache of drug-dependence by acup - mox ther has a significant effect.