A composite gel composed of collagen,alginate and synthetic HA powder was formed by using collagen assembly,and freeze-drying of the composite gel gave rise to collagen-alginate-HA porous materials.Scanning electron microscopy,X-ray diffraction,Fourier transform infrared spectroscopy and Ultra-violet spectroscopy were used to characterize the physiochemical properties of the prepared materials and to reveal the possible interactions between molecular species.The results indicated that the scaffolds had interconnected porous structure with typical pores ranging between 200-600μm.Inorganic phase,poorly crystallized hydroxyapatite,was formed uniform dispersion with the organic substances.The introduction of alginate,to some extent,influenced the collagen assembly process.The materials prepared in this study could be a promising scaffolds for bone tissue engineering.
