A 40-year-old man was hospitalized with anorexia, weakness and yellow urine for 3 days after 1 month of antituberculosis therapy.Physical examination showed mild yellow sclera and secondary pulmonary tuberculosis. He was diagnosed as tuberculosis and drug-induced hepalitis. The patient was treated with antituberculosis drugs,drugs for liver disorders, and intravenous infusion of tiopronin 0.2g/day. His appetite was improved, while weakness,yellow urine and sclera were partially resolved. Several days later, the patient developed chill and hyperpyrexia(39.5℃). The temperature was gradually returned to normality and chill was resolved 10 minutes after treatment of promethazine and aminopyrine. When the patient was given tiopronin the next day, chill and hyperpyrexia recurred. It was considered that the symptoms were associated with tiopronin, since no adverse reactions occured after tiopronin was discontinued.
