The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate(CaO x )were in-vestigated in silica gel with a doubl e diffusion technique.The ability o f inhibiting the growth and aggregation of CaO x crystal and the ability of inducing f ormation of COD follows:potassium c itratesodium citrate >citric acid.Na 2 EDTA had a stronger ability to inhibi t the aggregation of CaO x crystals than that of EDTA,but a weak er ability to inhibit nucleation and growth of C aO x crystals.Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD,t hat is,COD is easy to be expelled from the body along with the urine.So both inducing formation of COD and in hibiting growth and aggregation of CaO x crystal can decrease the probability of urinary stones.These results hav e positive significance in the prevention and cure of urinary stones clin ically.
