Efforts toward the total synthesis of indolactam V via CuI-mediated inter- and intra-molecular N-arylation of 4-iodotryptophan derivatives for the introduction of 4-valine moiety from natural L-valine are described. Meanwhile, the efficient synthesis of several pyrroloquinoline derivatives by taking advantage of the CuI-catalyzed intramolecular N-arylation reaction of 4-iodotryptophan is disclosed.
To investigate the chemical components of the barks and twigs ofltoa orientalis. A new linear monoterpene glycoside named itoside O was isolated from the crude extract of Itoa orientalis together with 11 known compounds. The new compound was identified to be 3,7-dimethyl-1, 6-octadien-3, 10-dihydroxyl-10-O-α-L-arabinopyranosyl （1 -→6）-O-β-D-glucopyranoside by 1D and 2D NMR analysis, and all known compounds were isolated from this plant for the first time.
Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 columns. The structures were elucidated by spectral analysis. Results Thirteen compounds were isolated and their structures were identified as （-）-syringaresinol （1）, syringaresinol-4-O-β-D-glucopyranoside （2）, syringaresinol-4,4′-bis-O-β-D-glucopyranoside （3）, （±）-catechin （4）, catechin-3-O- β-D-glucopyranoside （5）, catechin-5-O-β-D-glucopyranoside （6）, 1,3-bis-（4-hydroxy-3,5-dimethoxyphenyl）-1,3-propanediol （7）, （R）-（＋）-chaulmoogric acid （8）, friedelin （9）, uracile （10）, benzoic acid （11）, vaniUic acid （12）, and 4-hydroxybenzoic acid （13）. Conclusion All the compounds described above were isolated from this genus for the first time.
