Objective To investigate the effect of Zishengyutaiwan （ZSYTW）, a kind of traditional Chinese herbal medicine, in treating occult hyperprolactinemia （OHP） with early recurrent abortion. Methods Fifty-six cases of OHP were detected from 151 cases with cause-unknown recurrent abortion by thyroid-releasing hormone （TRH） load test, who were randomly divided into two groups, one group （31 cases） was treated with ZSYTW and the other （25 cases） with bromocriptine as controls. Serum levels of estradiol （E2） and progesterone （P） were measured and vaginal ultrasound scanning was performed on the 21st to 25th days of menstruation to measure their endometrial thickness for all the subjects before and after treatment. And, serum levels of P, prolactine （PL） and chorionic gonodotrophin （CGT） were measured within eight weeks of conception. Results There was no significant difference in serum level of E2 before and after treatment in both groups. But, serum level of P and endometrial thickness showed significant difference before and after treatment between two groups （P<0.05 and P<0.01, respectively）. Serum level of P indicated insufficient luteal function in one （3.4%） of 29 cases with ZSYTW after conception, with 27 successful pregnancy （87.1%） and two abortions, and insufficient luteal function in four cases （20.0%） of 20 cases with western medicine after conception, with 19 successful pregnancy （76.0%） and one abortion （P<0.05 and P>0.05, respectively）. Conclusions SOHP closely related to recurrent abortion. OHP in cause-unknown recurrent abortion could be detected by TRH load test. Traditional Chinese herbal medicine ZSYTW could improve luteal function and intro-environment of endometrium more than bromocriptine could.
