To investigate the effects of the Male Sterile Preparation (MSP-1),an alcoholic male chemosterilant,on sperm count and sperm motility of the male plateau pika,40 adult male plateau pikas were randomly divided into 4 groups (n=10/group) that received 0,20,40 or 60 mg/kg bw of MSP-1 (ig). The weight of body,testis,epididymis and the count,motility,malformation rate of sperm were analyzed after 19 days. The body,testis and epididymis weights were not significantly different (P>0.05) at any dose levels when compared with the control group. Sperm count,motility and survival rate were significantly decreased in the treated groups compared with the control group. The sperm deformity rates in the 40 mg/kg and 20 mg/kg groups were higher in than the control group. The sperm deformity rates in the 60 mg/kg group were significantly higher than in the control group with a significant difference (P<0.01). MSP-1 was produced sterility in plateau pika by reducing sperm count,motility,and increasing the rate of sperm deformity.
