The establishment of China-ASENfree trade area is a rare historical opportunity as well as an unprecedented challenge for Guangxi bordering on ASEAN.With the rapid development of the economic and trade cooperation with ASEAN,Guangxi’s enterprises are increasingly faced with the intellectual property rights issues relating to trade.The paper expounds the intellectual property rights issues in Guangxi and its present situation in ASEAN.Based on the patent search method,ten top technological fields are classified according to the statistical figures of the patent application of Guangxi,and the patent acceptance of Singapore and Thailand respectively.The trend of patent application and acceptance in eight industries is then analyzed and accordingly the intellectual property rights strategy in those industries of Guangxi is proposed for the economic and trade cooperˉation with ASEAN.It finally discusses its counter-measures in agriculture,mechanical and electrical industries and Chinese traditional medicine in Guangxi.