Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side effects.Astaxanthin(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory properties.However,it faces problems such as poor water solubility,photothermal instability,and low bioavailability.Here,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant capacity.In vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of inflammation.This work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.
The Myc gene is the essential oncogene in triple-negative breast cancer(TNBC).This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line.Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene.The nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan(Chi-Se-DEC),which was then encapsulated in niosome-nanocarriers(NISM@Chi-Se-DEC).FT-IR,DLS,FESEM,and hemolysis tests were applied to confirm its characterization and physicochemical properties.Moreover,cellular uptake,cellular toxicity,apoptosis,cell cycle,and scratch repair assays were performed to evaluate its anticancer effects on cancer cells.All anticancer assessments were repeated under X-ray irradiation conditions(fractionated 2Gy).Physicochemical characteristics of niosomes containing SeNPs and ODNs showed that it is synthesized appropriately.It revealed that the anticancer effect of NISM@Chi-Se-DEC can be significantly improved in combination with X-ray irradiation treatment.It can be concluded that NISM@Chi-Se-DEC nanocarriers have the potential as a therapeutic agent for cancer treatment,particularly in combination with radiation therapy and in-vivo experiments are necessary to confirm the efficacy of this nano-drug.
The authors regret that there is an error in the article Fig.9D1 due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading,and also a mislabled error in the supporting Information Fig.S9 and S10.
Yuling MaoXiudan WangCaishun ChenQinfu ZhaoYanfeng LiuJinghai ZhangSiling Wang
With the emergence of new therapeutic methods,synergistic therapy has attracted great attention because it can improve the treatment efficacy,and reduce the toxic side effects.Herein,we developed a nanocarrier BGT by co-loading glucose oxidase(GOD)and transferrin(TRF)on the porous Bi nanoparticles(NPs)for improving tumor synergistic therapy.GOD endows BGT with catalytic capacity of decomposing glucose into gluconic acid and a large amount of H2O2 for starving therapy.H2O2 further destroys TRF structure and releases Fe^(3+),which could react with H2O2 to generate highly toxic·OH for chemodynamic therapy(CDT).In addition,GOD-induced glucose depletion and decreased expression of heat shock proteins(HSPs)can also alleviate the thermotolerance of tumor cells to improve the efficiency of mild photothermal therapy(PTT).Mild temperature can in turn promote the production of reactive oxygen species(ROS)for improving the synergistic therapy.Combined with the excellent targeting ability of TRF,efficient tumor synergistic therapy can be achieved.This work shows that BGT has good photothermal stability and biocompatibility,and can be used as a nanocarrier,providing an effective method for collaborative therapy of tumor.
Cancer is currently one of the most intractable diseases causing human death.Although the prognosis of tumor patients has been improved to a certain extent through various modern treatment methods,multidrug resistance(MDR)of tumor cells is still a major problem leading to clinical treatment failure.Chemotherapy resistance refers to the resistance of tumor cells and/or tissues to a drug,usually inherent or developed during treatment.Therefore,an urgent need to research the ideal drug delivery system to overcome the shortcoming of traditional chemotherapy.The rapid development of nanotechnology has brought us new enlightenments to solve this problem.The novel nanocarrier provides a considerably effective treatment to overcome the limitations of chemotherapy or other drugs resulting from systemic side effects such as resistance,high toxicity,lack of targeting,and off-target.Herein,we introduce several tumor MDR mechanisms and discuss novel nanoparticle technology applied to surmount cancer drug resistance.Nanomaterials contain liposomes,polymer conjugates,micelles,dendrimers,carbon-based,metal nanoparticles,and nucleotides which can be used to deliver chemotherapeutic drugs,photosensitizers,and small interfering RNA(siRNA).This review aims to elucidate the advantages of nanomedicine in overcoming cancer drug resistance and discuss the latest developments.
