The treatment of prostate cancer(PCa)needs to be improved.1 Micro-RNAs(miRNAs)are a subtype of non-coding,single-stranded RNAs that influence cellular survival and death by modulating mRNAs.Among these miRNAs,MIR375 has a critical role in the regulation of tumorigenesis?and holds promise as a novel therapeutic target for future PCa treatment.Recombinant adeno-associated virus(rAAV)exhibits non-pathogenicity,low-grade inflammation,and robust and long-lasting expressions of target genes.We have previously described the rAAv9 as a valid vector to transfer target miRNAs and genes,3 so rAAv9 could be used as a vector to deliver MIR375 into the mouse prostate and PCa cells.
Xianyanling YiJin LiZeyu HanTianyi ZhangDazhou LiaoJia YouJianzhong Ai
Most disturbed habitats in the tropics and subtropics harbor numerous species of invasive ants, and occasionally the same species has been introduced repeatedly from multiple geographical sources. We examined how experimental crossbreeding between sexuals from different populations affects the fitness of queens of the tramp ant Cardiocondyla itsukii, which is widely distributed in Asia and the Pacific Islands. Eggs laid by queens that mated with nestmate males had a higher hatchi ng rate than eggs laid by queens mated to males from neighboring (Hawaii x Kauai) or distant introduced populations (Hawaii/Kauai x Okinawa). Furthermore, inbreeding queens had a Ion ger lifespan and produced a less female-biased offspring sex ratio than queens from allopatric mating. This suggests that the genetic divergence between different source populations may already be so large that in case of multiple invasions eventual crossbreeding might negatively affect the fitness of tramp ants.
