目的:本研究的目的是构建一个包括人格特质调节作用的中介模型,以探讨青少年家庭功能、社会支持和压力的影响和机制。方法:2021年7月至9月进行全国横断面调查,从中国居民心理学与行为调查数据库中收集了1064份12~18岁青少年的有效数据。通过相关性分析、中介效应分析和调节效应分析构建家庭功能、社会支持、压力和大五人格的理论模型。结果:家庭功能对压力有显著的负向预测作用,社会支持在家庭功能和压力之间起中介作用。外倾性和开放性正向调节家庭功能和社会支持的关系,宜人性、神经质和尽责性则是负向调节。结论:健康的家庭功能能够降低青少年压力水平,并通过增强社会支持的正向作用来间接减轻压力,其中外倾性和开放性人格特质对家庭功能和社会支持关系的调节作用尤为显著。Objective: The aim of this study was to construct a mediation model that included the moderating role of personality traits to explore the effects and mechanisms of adolescent family functioning, social support, and stress. Methods: A national cross-sectional survey was conducted from July to September 2021. Valid data from 1064 adolescents aged 12~18 years were collected from the Chinese Psychological and Behavior Survey Database. The theoretical model of family function, social support, stress, and Big Five personality was constructed by correlation analysis, mediating effect analysis, and moderating effect analysis. Results: Family function had a significant negative predictive effect on stress, and social support played a mediating role between family function and stress. Extraversion and openness positively moderated the relationship between family function and social support, while agreeableness, neuroticism, and conscientiousness negatively moderated the relationship between family function and social support. Conclusion: Healthy family functioning can reduce the stress level of adolescents and i