To the Editor:Childhood obesity is a serious public health concern that can have long-term impacts on physical and psychological health.Lifestyle interventions have been widely used to treat childhood obesity.Notably,individual responses to the same intervention differ by genetic background.Previous researchers have explored the moderating effects of several glucose-metabolism-related genes on childhood obesity interventions,including TCF7L2[1]and RPTOR.[2]Nevertheless,these studies have been limited in study designs(without a control group)and duration(no more than a year),and no studies have explored the effect of the INSR(another glucose-metabolism-related gene)variants.Moreover,previous studies have focused only on single nucleotide polymorphism(SNP)-based analyses instead of gene-based analyses on the present topic.As such,we examined the associations of the INSR gene variants with the response to lifestyle-based obesity intervention in Chinese children aged 8-10 years at both gene-and SNP-levels.
Jing ChenRui ShanJieyun SongHui WangWucai XiaoShuang ZhouAiyu GaoFang ZhangZheng Liu
